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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CACNA1B All Species: 6.67
Human Site: T2024 Identified Species: 14.67
UniProt: Q00975 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00975 NP_000709.1 2339 262496 T2024 P M K R S I S T L A Q R P R G
Chimpanzee Pan troglodytes XP_520396 2784 310342 T2470 P M K R S I S T L A Q R P R G
Rhesus Macaque Macaca mulatta XP_001110352 2383 269535 N2042 S M E R S S E N T Y K S R R R
Dog Lupus familis XP_537779 2046 229120 A1735 K R S I S T L A P Q R P H V A
Cat Felis silvestris
Mouse Mus musculus O55017 2327 261463 S2014 S P M K R S I S T L A P R P H
Rat Rattus norvegicus Q02294 2336 262238 S2023 S P M K R S I S T L A P R P H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus O73700 2190 249326 G1845 T Y I R S D S G D G R R P T I
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q2XVR3 1829 207718 D1518 I L N S G P P D C D P D F E N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91645 1851 212452 G1540 P G H S Y M N G H R R S P S L
Honey Bee Apis mellifera NP_001159376 1904 215872 R1593 M L D L L I P R N E E I G R G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001186699 1966 222605 S1655 N S R A I E M S D I R Y R D R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 82.1 54.2 80.1 N.A. 91.9 92.1 N.A. N.A. 38.3 N.A. 20.7 N.A. 44.7 47.6 N.A. 39.5
Protein Similarity: 100 82.3 65.5 82.2 N.A. 94.4 94.5 N.A. N.A. 53.3 N.A. 36 N.A. 56 58.7 N.A. 52.4
P-Site Identity: 100 100 26.6 6.6 N.A. 0 0 N.A. N.A. 33.3 N.A. 0 N.A. 13.3 20 N.A. 0
P-Site Similarity: 100 100 40 13.3 N.A. 13.3 13.3 N.A. N.A. 40 N.A. 6.6 N.A. 33.3 33.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 0 0 0 10 0 19 19 0 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % C
% Asp: 0 0 10 0 0 10 0 10 19 10 0 10 0 10 0 % D
% Glu: 0 0 10 0 0 10 10 0 0 10 10 0 0 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % F
% Gly: 0 10 0 0 10 0 0 19 0 10 0 0 10 0 28 % G
% His: 0 0 10 0 0 0 0 0 10 0 0 0 10 0 19 % H
% Ile: 10 0 10 10 10 28 19 0 0 10 0 10 0 0 10 % I
% Lys: 10 0 19 19 0 0 0 0 0 0 10 0 0 0 0 % K
% Leu: 0 19 0 10 10 0 10 0 19 19 0 0 0 0 10 % L
% Met: 10 28 19 0 0 10 10 0 0 0 0 0 0 0 0 % M
% Asn: 10 0 10 0 0 0 10 10 10 0 0 0 0 0 10 % N
% Pro: 28 19 0 0 0 10 19 0 10 0 10 28 37 19 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 10 19 0 0 0 0 % Q
% Arg: 0 10 10 37 19 0 0 10 0 10 37 28 37 37 19 % R
% Ser: 28 10 10 19 46 28 28 28 0 0 0 19 0 10 0 % S
% Thr: 10 0 0 0 0 10 0 19 28 0 0 0 0 10 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 10 0 0 0 0 10 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _